Exploration of pharmacokinetic parameters and influencing factors of vancomycin in patients with renal replacement therapy co-infection: a single-center prospective clinical study

Exploration of pharmacokinetic parameters and influencing factors of vancomycin in patients with renal replacement therapy co-infection: a single-center prospective clinical study - Exploration of pharmacokinetic parameters and influencing factors of vancomycin in patients with renal replacement therapy co-infection

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300069316

Enrollment

Unknown

Registered

2023-03-13

Start date

2023-03-13

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal replacement therapy co-infection

Interventions

Group of renal replacement therapy co-infection:Therapeutic drug monitoring. Determination of vancomycin in dialysis waste fluid. Measurement of creatinine and urea nitrogen in blood samples and dialy

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. At least 18 years old; 2. Patients treated with intravenous vancomycin; 3. Receive renal replacement therapy.

Exclusion criteria

Exclusion criteria: 1. Pregnant women; 2. Patients who interrupt renal replacement therapy due to clinical or technical reasons; 3. Patients who cannot obtain written informed consent; 4. Patients died within 24 hours after admission; 5. Other patients to be excluded.

Design outcomes

Primary

Measure	Time frame
Vancomycin blood through concentration;Area under the 24-hour drug-time curve;Vancomycin concentration in dialysis fluid;Creatinine and urea nitrogen concentrations in blood and dialysis fluid;Compliance rate of blood drug trough concentration;	—

Secondary

Measure	Time frame
Clinical efficiency;Incidence of adverse reactions;	—

Countries

China

Contacts

Public ContactDing Nan

Shanghai Changhai Hospital

609123572@qq.com+86 13916343667

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026