Type 2 diabetes kidney disease
Conditions
Interventions
Experimental group:Tangshen Fang+Standard Western Medicine±Traditional Chinese Medicine
Control group:Standard Western Medicine±Traditional Chinese Medicine
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years, no gender limit; 2. Clearly diagnosed type 2 diabetes; Glycosylated hemoglobin =30mg/g, or eGFR: 25 ~ <60 ml/min/(1.73m^2) with UACR<30mg/g; And last for more than 3 months; 4. TCM syndrome differentiation mainly consists of Qi and Yin deficiency with blood stasis; 5. Sign informed consent and cooperate with follow-up visits.
Exclusion criteria
Exclusion criteria: 1. Patients with severe diabetes and major vascular events within six months; 2. Various infections within four weeks; 3. Combined use of Uiduqing Granules and Shenshuaining capsules; 4. Pregnant or lactating patients who are allergic to the test drug; 5. Complicated with other serious diseases, such as blood system diseases, malignant tumors, severe heart failure, obvious liver diseases; 6. Uncontrolled hypertension (SBP>=160 mmHg and/or DBP>=100 mmHg); 7. Patients with mental illness or incapacity; 8. Kidney disease not caused by diabetes has been identified; 9. Hyperkalemia (blood potassium > 5.5mmol/L).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in eGFR levels from baseline to week 24; | — |
Secondary
| Measure | Time frame |
|---|---|
| Urine protein/creatinine ratio (UACR) from baseline at 24 weeks;Change in body weight from baseline to week 24;Change in body blood pressure(systolic and diastolic) from baseline to week 24;Change in fasting lipid profile (TC, LDL-C, HDL-C, TG) from baseline to week 24;Change in fasting plasma glucose from baseline to week 24;Change in HbA1c from baseline to week 24;Improvement in TCM symptoms(evaluated by TCM symptom assessment score)from baseline to week 24;Improvement in quality of life from baseline to week 24;Change in waist circumference from baseline to week 24; | — |
Countries
China
Contacts
Public ContactChen Xiaoping
China-Japan Friendship Hospital
Outcome results
None listed