The clinical efficacy and safety of oblique lateral interbody fusion in the treatment of degenerative lumbar spondylolisthesis: a randomized controlled trial

The clinical efficacy of OLIF in the treatment of lumbar degeneration

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300069267

Enrollment

Unknown

Registered

2023-03-10

Start date

2023-03-10

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Degenerative lumbar spondylolisthesis

Interventions

OLIF group:Obllque lumber Interbody fusion, OLIF

TLIF group:Transforaminal lumbar interbody fusion, TLIF

PLIF group:Posterior lumbar interbody fusion, PLIF

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. The clinical manifestations were acute or chronic low back pain with or without intermittent claudication, which obviously affected daily work and life and could not be relieved after 6 months of strict non-surgical treatment; 2. Preoperative imaging examination (X-ray, CT or MRI) showed signs of lumbar spondylolisthesis with Meyerding classification of degree ? or ? and single-segment lesions (L2/3-L4/5). 3. Aged over 18 years; 4. Dynamic position radiographs of the lumbar spine showed intervertebral instability at the responsible level; 5. No obvious surgical contraindications were found in conventional laboratory and imaging examinations; 6. The patient and his/her family members consented and volunteered to participate in the clinical trial.

Exclusion criteria

Exclusion criteria: 1. Patients with spinal deformity (rotation and scoliosis); 2. Lumbar tumor, lumbar infection, lumbar fracture, etc.; 3. Severe osteoporosis; 4. Osseous lumbar spinal stenosis caused by ossification of posterior longitudinal ligament, osteophyte of posterior endplate, osteoplasia of facet joints, congenital spinal stenosis and other factors; 5. History of posterior lumbar or abdominal surgery; 6. There were huge disc herniation, annulus fibrosus rupture and nucleus pulposus prolapse in the lesion segment.

Design outcomes

Primary

Measure	Time frame
Visual Analogue Scale Score;Oswestry Disability Index (ODI) Score;operation time;intraoperative blood loss;postoperative drainage;postoperative hospital stay;complications (infections, dural tear, nerve injury etc.);	—

Secondary

Measure	Time frame
lumbar lordosis (LL);fused segment lordosis;intervertebral space height (ISH);intervertebral foramen height (IFH);fusion rate;	—

Countries

China

Contacts

Public ContactLiu Weiqiang

Weifang People's Hospital

liuwqspine@126.com+86 187 6510 9800

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026