Correlation between morphology of meibomian gland and changes of corneal nerve in patients with type 2 diabetes mellitus by confocal microscopy

Status

Active, not recruiting

Phases

Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2300069252

Enrollment

Unknown

Registered

2023-03-10

Start date

2023-04-01

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes

Interventions

Diabetes group:N/A

Normal control group :N/A

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Clinical diagnosis of type 2 diabetes mellitus. 2. Aged > 18 years. 3. Corneal transparency. 4. Confocal microscopy showed decreased corneal nerve density. 5. Corneal sensitivity with or without reduction.

Exclusion criteria

Exclusion criteria: 1. Concomitant keratopathy. 2. Glaucoma combined with poor intraocular pressure control. 3. Wear contact lenses for a long time. 4. Corneal trauma. 5. History of corneal refractive surgery. 6. Use eye drops and creams for a long time. 7. Autoimmune diseases. 8. Postoperative craniocerebral nerve injury.

Design outcomes

Primary

Measure	Time frame
Corneal neuromorphism;Degree of corneal epithelial defect;Corneal sensitivity;Tear break-up time, TBUT;Schirmer I test;Meibomian gland acini&dendritic cells;	—

Countries

China

Contacts

Public ContactSun Dapeng

Qingdao Eye Hospital, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Science

1144309423@qq.com+86 13963903493

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026