Effects of different administration methods of esketamine on inflammatory indicators in EBC and prognosis among patients undergoing thoracoscopic pulmonary surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300069247

Enrollment

Unknown

Registered

2023-03-10

Start date

2023-04-01

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Group K :Inhalation of esketamine before induction of anesthesia

Group C :Inhalation of normal saline before induction of anesthesia

Group KI :Inhalation of esketamine after one-lung ventilation

Group KV :Continuous intravenous pumping of esketamine after one-lung ventilation

Group N :Inhalation of normal saline after one-lung ventilation

Eligibility

Sex/Gender

All

Age

45 Years to 74 Years

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for elective thoracoscopic lung surgery under general anesthesia were selected; 2. Patients aged 45-74 years, with ASA grade I to ?, no gender limit.

Exclusion criteria

Exclusion criteria: 1. Patients with severe cardiovascular and cerebrovascular diseases; 2. Patients with severe liver and kidney dysfunction; 3. Preoperative lung function measurement was 65% lower than the expected value; 4. Long-term use of opioid medicines; 5. Patients with lung infection or systemic infection; 6. Recent use of anti-inflammatory drugs or antioxidant drugs; 7. Long-term use of glucocorticoid or immunosuppressant; 8. History of allergy to esketamine or contraindications to the use of esketamine (serious risk of elevated blood pressure and intracranial pressure, poorly controlled or untreated hypertension, untreated or undertreated hyperthyroidism, gastrointestinal bleeding); 9. Mental illness and other chronic pain or other conditions that may confuse the analgesic response; 10. Emergency surgery or trauma patients; 11. Previous history of thoracotomy or intraoperative awareness.

Design outcomes

Primary

Measure	Time frame
inflammatory factors and oxidative stress factors in serum and EBC;hemodynamics;	—

Secondary

Measure	Time frame
drainage tube removal time;postoperative recovery of gastrointestinal function;incidences of adverse reactions;hospital stays;the incidence of PPCs and other complications;respiratory mechanics parameters;time to get out of bed after surgery;consumptions of the opioids drugs;pain score;	—

Countries

China

Contacts

Public ContactYao Lei

The Second Affiliated Hospital of Nantong University

yaoleijiangsu1987@163.com+86 18862920110

Outcome results