precocious puberty
Conditions
Interventions
precocious puberty group:N/A
precocious puberty and obesity group:N/A
control group:N/A
Sponsors
Fuzhou Children's Hospital of Fujian Province
Eligibility
Sex/Gender
Female
Age
6 Years to 10 Years
Inclusion criteria
Inclusion criteria: 1. Girls with idiopathic central precocious puberty are diagnosed according to the consensus on diagnosis and treatment of central precocious puberty published by Endocrinology, Genetics and Metabolism Group, Pediatrics Branch of the Chinese Medical Association in 2015: (1) The girl develops secondary sexual characteristics before 8 years of age or menarche before 10 years of age and the symptoms persist; (2) Linear growth acceleration occurs; (3) There was advanced bone age, which was more than 1 year older than the actual age; Or advanced growth, bone age growth/actual age growth > 1; (4) B-ultrasound examination showed evidence of gonadal development: the volume of uterus and ovary increased, at least one ovary volume was greater than 1mL, and the diameter of more than one follicle was greater than 4 mm; (5) Hypothalamic-pituitary-gonadal axis function activation: The LH peak >=5.0 U/L and LH peak /FSH peak >= 0.6 in the GnRH stimulation test were taken as the critical criteria to judge the gonadal axis function activation. 2. Obesity: age-specific BMI was used to define obesity. BMI is calculated as weight (kg) divided by height squared (m^2). The BMI threshold corresponds to a BMI defining obesity at age 18 of 28 kg/m^2 (greater than 96.3% for boys and 98% for girls). 3. Obese precocious puberty group: obese according to BMI; Idiopathic central precocious girls. 4. Simple obesity: obese according to BMI; A girl with no breasts. 5. Simple premature puberty group: body weight and BMI were calculated in the normal range; Idiopathic central precocious girls. 6. Normal control group: body weight and BMI were calculated in the normal range; A girl with no breasts.
Exclusion criteria
Exclusion criteria: 1. The patient had clear organic diseases (such as ovarian tumor, hamartoma, etc.), chronic diseases (such as chronic kidney disease, asthma, epilepsy, etc.), and genital abnormalities (such as cryptorchidism, hypospadias, etc.); 2. The patient has previously received hormone-type drugs or drugs with definite effects on the reproductive axis; 3. Aged 10 years; 4. The patient was diagnosed as peripheral or partial precocious puberty; 5. Recent use of drugs; 6. Significantly abnormal liver and kidney function (alanine aminotransferase or aspartate aminotransferase > 2 times of the normal upper limit, creatinine or urea nitrogen exceeds the normal upper limit); 7. Recent history of infectious diseases or use of antibiotics; 8. Failure to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| proteomics;metabolomics; | — |
Countries
China
Contacts
Public ContactZhang Ying
Fuzhou Children's Hospital of Fujian Province
Outcome results
None listed