Stroke
Conditions
Interventions
Study 1: Stroke group:intermittent Theta burst magnetic stimulation (TBS)
Study 1: Healthy control group:intermittent Theta burst magnetic stimulation (TBS)
Study 2: Regular training group:Regular training
Study 2: Sham stimulation group:Routine training+iTBS in M1 area of the affected side+false stimulation of SMA on the affected side
Study 2: Experimental group:Routine training group+affected side M1 and SMA iTBS
Sponsors
Huashan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria of healthy people: (1) Aged 18-80 years and the gender is not limited; (2) Clear consciousness and stable vital signs; (3) Be aware of this research and voluntarily sign the informed consent. 2. Inclusion criteria of patients: (1) Meet the diagnostic criteria of stroke in the Fourth National Conference on Cerebrovascular Disease; (2) First subcortical stroke; (3) Hemiplegia, Brunnstrom grade upper limb and hand ?-?; (4) The Modified Ashworth Scale (MAS) was lower than grade 2; (5) Aged 18-80 years, and the course of disease was 6-12 months; (6) Clear consciousness and stable vital signs; (7) Know about this research and sign the informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for healthy people: (1) Diseases of the nervous system, bone and joint, and muscles that affect motor function; (2) Severe cardiopulmonary, liver and kidney dysfunction; (3) Epilepsy; (4) Severe cramps or pain; (5) Severe speech, attention, hearing, vision, sensory, intellectual, mental or cognitive impairment; (6) History of malignant tumor disease; (7) Patients with metal objects or magnetic plates in the skull, cardiac pacemakers, medical implant devices such as cardiac wires and central venous catheters; (8) Patients with malignant hypertension. 2. Exclusion criteria for patients: (1) Diseases of bone, joint and muscle; (2) Other serious neurological diseases; (3) Complicated with severe cardiopulmonary, liver and kidney dysfunction; (4) Epilepsy; (5) Severe spasms or pain; (6) Severe speech, attention, hearing, visual, sensory, intellectual, mental or cognitive impairment (MMSE>24/30); (7) History of malignant tumor disease; (8) Patients with metal objects or magnetic plates in the skull, cardiac pacemakers, medical implant devices such as cardiac wires and central venous catheters; (9) Patients with malignant hypertension.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diffusion tensor imaging indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Simplified Fugl-Meyer Assessment (FMA) Score;Action Research Arm Test Assessment Score;Wolf Motor Function Test Assessment Score;Barthel Index Assessment Score;Brunnstrom Rating Scale;fNIRS indicators;Indicators of cortical excitability; | — |
Countries
China
Contacts
Public ContactWang Yuyuan
Huashan Hospital Affiliated to Fudan University
Outcome results
None listed