The effect and epigenetic mechanism of combining Baduanjin training and vitamin D supplementation on frail older adults

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300069201

Enrollment

Unknown

Registered

2023-03-09

Start date

2023-03-20

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Frailty

Interventions

Blank Control Group:None

Baduanjin Group:Baduanjin training

Vitamin D Group:Vitamin D supplementation

Combined Intervention Group:Baduanjin training combined with Vitamin D supplementation

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Frailty phenotype score >=3 points; 2. Aged >=65 years; 3. No auditory or visual impairment; 4. Participate voluntarily and sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Cognitive dysfunction (Mini-Mental State Examination, MMSE<21); 2. Have been diagnosed with cardiovascular and cerebrovascular diseases, severe kidney diseases, diabetes or complications, or have any symptoms or signs related to cardiovascular diseases; 3. Unable to walk independently, such as in a wheelchair or using a walker; 4. Participated in other intervention studies within 3 months before enrollment.

Design outcomes

Primary

Measure	Time frame
Frailty;CYP2R1 methylation level;CYP27B1 methylation level;CYP24A1 methylation level;GC methylation level;VDR methylation level;	—

Secondary

Measure	Time frame
25-OH-D3;1,25(OH)2D3;	—

Countries

China

Contacts

Public ContactChen Si

School of Nursing and Rehabilitation, Shandong University

chensi@sdu.edu.cn+86 155 5002 8069

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026