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A multicenter historical prospective study on the relationship between the expression of MMR protein in prostate cancer tissue and the clinicopathological characteristics of prostate cancer

A multicenter historical prospective study on the relationship between the expression of MMR protein in prostate cancer tissue and the clinicopathological characteristics of prostate cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300069200
Enrollment
Unknown
Registered
2023-03-09
Start date
2023-03-16
Completion date
Unknown
Last updated
2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prostate cancer

Interventions

Case series:N/A

Sponsors

Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: 1. Pathologically confirmed prostate adenocarcinoma; 2. Prostate cancer tissue can be obtained for immunohistochemical staining of MLH1, MSH2, MSH6 and PMS2 MMR proteins;

Exclusion criteria

Exclusion criteria: 1. Patients with life expectancy less than 1 year; 2. Patients with other tumor diseases; 3. Prostate cancer with other pathological types other than adenocarcinoma; 4. Patients who have received immunosuppressive therapy or have immune deficiency diseases; 5. Patients with severe liver function damage (Child-Pugh C); 6. Patients with severe renal function injury requiring long-term dialysis treatment; 7. Patients with severe myelosuppression and severe neutropenia; 8. Participate in other clinical studies from 30 days before enrollment to the completion of this study.

Design outcomes

Primary

MeasureTime frame
Progress-free survival;

Secondary

MeasureTime frame
Overall survival;Proportion of Patients With PSA Complete Response;Clinial stage;Pathological grade;

Countries

China

Contacts

Public ContactChunguang Yang

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

cgyang-hust@hotmail.com+86 13871084024

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026