congenital heart disease
Conditions
Interventions
Placebo group:receive identical syringes labeled with the randomization number contained saline solution
Low dose of tranexamic acid group:loading dose 15 mg/kg
maintenance dose 5 mg/kg.h
High dose of tranexamic acid group:loading dose 30 mg/kg
maintenance dose 10 mg/kg.h
Sponsors
Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients eligible for randomization were men and women aged 0 day to 31 days ; 2. undergoing primary cardiac surgery with cardiopulmonary bypass; 3. Agreed to participate in the study and signed an informed consent.
Exclusion criteria
Exclusion criteria: Patients excluded from the study were those with previous cardiac surgery, preoperative hemoglobin level of <90 g/L, chronic renal insufficiency, chronic hepatic insufficiency, coagulant function abnormality, recent history of anticoagulant therapy, allergy to tranexamic acid.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total postoperative blood loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| The volume and exposure of allogeneic transfusion;The incidence of reoperation for bleeding; | — |
Countries
China
Contacts
Public ContactYu Zhang
Department of Anesthesiology, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed