pancreatic cancer
Conditions
Interventions
Unresectable pancreatic cancer:Utidelon injection in combination with gemcitabine therapy
Sponsors
Shanghai First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients enrolled in the study must meet all of the following criteria: (1) Age: 18-75 years old. (2) Karnofsky (KPS) physical status score =70. (3) Those confirmed by histopathology or cytology, inoperable and unsuitable for local treatment This is a malignant tumor of pancreatic ductal epithelium, graded as stage ?-? according to the AJCC eighth Edition (T4NxM0-1/TxNxM1), except for pancreatic neuroendocrine tumors; (4) Baseline blood routine and biochemical indexes of subjects meet the following standards: hemoglobin =90g/L; neutral Granulocyte absolute count (ANC) =1.5×109g/L; Platelet =100×109/L; glutamine Enzyme (ALT), aspartate aminotransferase (AST) =2.5 times the normal upper limit; Serum total bilirubin <1.5 times the normal upper limit; Serum creatinine <1 times the normal upper limit; Serum albumin =30g/L. (5) Cardiac function: a) left ventricular ejection fraction (LVEF) =50%; b) 12-ECG showed no myocardial ischemia; c) No history of arrhythmia requiring drug intervention before enrollment; (6) No severe concomitant disease with survival time <5 years, known peripheral nerve disease = grade 1. (7) Agree to and be able to follow the protocol during the study. (8) Provide written informed consent before entering the study screening.
Exclusion criteria
Exclusion criteria: (1) For patients with pancreatic cancer who had previously received chemotherapy, radiotherapy or immunotherapy. (2) Patients with pancreatic neuroendocrine tumors confirmed by histopathology or cytology (3) Pregnant or lactating women. (4) Women of childbearing age who had a positive pregnancy test at baseline or did not undergo a pregnancy test. Postmenopausal women must Stop menstruation for at least 12 months before pregnancy is not possible. (5) Men and women who had sex (with the possibility of procreation) were reluctant to use contraception during the study period. (6) Non-melanoma skin cancer and cervical carcinoma in situ were cured in patients with other malignant history in the last 5 years Outside. (7) A history of uncontrolled epilepsy, central nervous system disease or mental disorder, as determined by the investigator Clinical severity can prevent the signing of informed consent or affect patient adherence to oral medication. (8) Clinically severe (i.e. active) heart disease, such as symptomatic coronary heart disease, New York Heart Association May have grade II or worse congestive heart failure or severe cardiac rhythm requiring medical intervention Disorder, or history of myocardial infarction within the last 12 months. (9) Those who are severely allergic to polyoxyethylene (35) castor oil, or have used anti-microtubule drugs in the past Severe adverse reactions occurred. (10) Known peripheral nerve disease =NCI, CTC, AE grade 2. (11) severe uncontrolled recurrent infection, or other severe uncontrolled concomitant disease. (12) Moderate or severe renal impairment [creatinine clearance =50ml/min (according to Cockroft and Gault equation), or serum creatinine > upper normal limit (ULN) . (13) Acute or chronic active hepatitis B, hepatitis C infection, hepatitis B virus (HBV) DNA > 2000IU/ml or 104 copies /ml, Hepatitis C virus (HCV) RNA > 103 copies /ml, hepatitis B surface antigen (HbsAg) and anti-HCV antibody positive at the same time, human immunity Epidemic defect virus (HIV). (14) Allergic to eutidrone or gemcitabine. (15) Participants who had received study medication or preparation/treatment (i.e., participating in other trials) within 4 weeks prior to enrollment. (16) Patients who were not eligible to participate in the study for any reason determined by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall survival;progression free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| objective response rate;Duration of Response; | — |
Countries
China
Contacts
Public ContactQi Li
Shanghai First People's Hospital
Outcome results
None listed