disorder of consciousness
Conditions
Interventions
spinal cord stimulation:spinal cord stimulation
Tranauricular vagus nerve stimulation:Tranauricular vagus nerve stimulation
high-definition transcranial direct current:High-definition transcranial direct current
combined treatment1:spinal cord stimulation combined with high-definition transcranial
combined treatment2:combined treatment by sham stimulation
Sponsors
Beijing Tiantan Hospital, Capital Medical University, Beijing
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1Diagnosis as MCS by CRS-R 2Age From 18 to 60 years 3More than 1 months after initial brain injury 4Consciousness was in a stable phase for at least 2 weeks before admission 5?No cranial defect or extensive skull repair 6?Patient's family agreed to the experimental protocol and had signed an informed consent
Exclusion criteria
Exclusion criteria: 1Neurodegenerative diseases such as Alzheimers disease and Lewy body dementia 2Those who were not expected to survive long 3Time since onset is less than 1 month(acute coma) 4?Seizures is difficulty to control 5?Those who are undergoing other clinical trial 6?Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coma Recovery Scale-Revised;Nociception Coma Scale;neuron-specific enolase; | — |
Secondary
| Measure | Time frame |
|---|---|
| EEG;Functional Nuclear Magnetic Resonance;Functional near-infrared spectroscopy; | — |
Countries
china
Contacts
Public ContactHe jiang hong
Beijing Tiantan Hospital, Capital Medical University
Outcome results
None listed