infertility
Conditions
Interventions
AI assisted embryo screening group ( experimental group ):Artificial intelligence assisted embryo screening
Artificial screening embryo group (Control group):Artificial screening embryo
Sponsors
The First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
Female
Age
35 Years to 42 Years
Inclusion criteria
Inclusion criteria: 1.Couples with IVF / ICSI indications ,female aged between 35-42 years old and BMI in the range of 18-30kg/m2; 2.Infertile female who underwent the first or second cycle of IVF-ET/ ICSI-ET treatment; 3.Routine controlled ovarian stimulation with long GnRH agonistGnRH antagonist protocol or luteal phase ovarian stimulation; 4.The number of oocytes obtained = 6; 5.Normal fertilized embryos are continuously cultured in time-lapse; 6.All D3 cultured into blastocysts, and D5 / 6 / 7 blastocysts = 2, and the morphological rating was above 4BC / 4CB; 7.Fully informed understanding of this study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Infertility patients treated with PGT; 2.Uterine septum, unicornuate uterus, double uterus and other reproductive tract malformations; 3.Intrauterine adhesions, uterine effusion, multiple endometrial polyps, submucous uterine fibroids or thin endometrium ( embryo transfer day endometrial thickness < 7mm ); 4.Patients with hydrosalpinx who were not treated with tubal ligation or blockage; 5.Patients with a history of autoimmune or endocrine diseases : systemic lupus erythematosus ( SLE ), undiferentiated connective tissue disease( anti-ANA positive ), hyperthyroidism, hypothyroidism, etc. 6.Recurrent implantation failure(no pregnancy after 3 or more high quality embryo transfer)or unexplained early pregnancy loss at least twice; 7.At least one of the couples has IVF or ICSI contraindications ( such as poorly controlled type I or type II diabetes unexplained liver disease or liver dysfunctionrenal disease or renal dysfunctionsevere anemiahistory of deep vein thrombosis, pulmonary embolism, cerebrovascular accidentpoorly controlled hypertension or diagnosed heart diseasehistory of cervical cancer, endometrial cancer or breast cancerunexplained vaginal bleeding, etc ).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ongoing pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| live birth rate;miscarriage rate;clinical pregnancy rate; | — |
Countries
China
Contacts
Public ContactQingyun Mai
The First Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed