neonatal congenital heart disease
Conditions
Interventions
Pre-experimental control group:Injected heparin dose is 400U/kg
Pre-experimental high-dose group 1:Injected heparin dose is 500U/kg
Pre-experimental high-dose group 2:Injected heparin dose is 600U/kg
control group:Injected heparin dose is 400U/kg
optimal dose group:Optimum Heparin Dose in Pre-injection Experiment
Sponsors
Fuwai Hospital, National Center for Cardiovascular Diseases
Eligibility
Sex/Gender
All
Age
No minimum to 0.1 Years
Inclusion criteria
Inclusion criteria: 1. Neonates with congenital heart disease =28 days old; 2. American Society of Anesthesiologists (ASA) rating: I-?; 3. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Newborns with congenital heart disease suffering from coagulation dysfunction before operation; 2. Neonates with congenital heart disease combined with severe liver and kidney dysfunction or neurological diseases before operation; 3. Extracorporeal life support is required before surgery; 4. Unknown preoperative blood type or lack of coagulation-related examinations; 5. Intraoperative extracorporeal circulation time > 3 hours, or operation time > 5 hours; 6. Has participated in other clinical research projects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| prothrombin fragment F1+2; | — |
Secondary
| Measure | Time frame |
|---|---|
| Thoracic drainage 24 hours after surgery;Usage of blood products 24 hours after surgery;Blood clotting index eight;Coagulation factor;Activated Clotting Time of WholeBlood; | — |
Countries
China
Contacts
Public ContactLiu Jingping
Outcome results
None listed