Rectal cancer
Conditions
Interventions
Experimental group:High ligation of the inferior mesenteric vein with left colic artery-preserving D3 lymph node dissection
Control group:Low ligation of the inferior mesenteric vein with left colic artery-preserving D3 lymph node dissection
Sponsors
The first Medical Center of Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age: 18–75 years old; 2. Patients diagnosed with malignant tumors confirmed by colonoscopic pathological biopsy and indicated for laparoscopic radical resection of rectal cancer; 3. Preoperative imaging revealing the clinical stage of the tumor to be Stage I (T2N0M0), II (T3-4N0M0), or III (T1-4N1M0 or T1-4N2M0) based on the American Joint Committee on Cancers (AJCC) TNM Staging System for Colorectal Cancer (Eighth edition, 2017); 4. Pelvic or rectal MRI to complete the evaluation of the clinical stage of the tumor; 5. American Society of Anesthesiologists grade I-III; 6. Patients or family members willing to participate and cooperate in the study.
Exclusion criteria
Exclusion criteria: 1. A history of other malignant tumors and abdominal vascular surgery; 2. Patients contraindicated for laparoscopic surgery (such as those with extensive adhesion caused by a previous major abdominal surgery or patients not suitable for pneumoperitoneum); 3. Patients with intestinal obstruction, perforation, or bleeding and other conditions requiring emergency surgery; 4. Pregnant or lactating women; 5. Patients who plan to participate in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3-year disease-free survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of harvested lymph nodes;Operative time;Postoperative (within 30 days) morbidity and mortality; | — |
Countries
China
Contacts
Public ContactXiaohui Du
The First Medical Center of Chinese PLA General Hospital
Outcome results
None listed