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The correlation between anhedonia symptoms and NMDA neural activity in the primary motor cortex in patients with depressive disorders:A case-control study

The correlation between anhedonia symptoms and NMDA neural activity in the primary motor cortex in patients with depressive disorders:A case-control study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300069132
Enrollment
Unknown
Registered
2023-03-07
Start date
2023-03-09
Completion date
Unknown
Last updated
2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depressive disorder

Interventions

Anhedonic depression disorder group:Paired transcranial magnetic stimulation, monetary incentive delay task
Non-anhedonic depression disorder group:Paired transcranial magnetic stimulation, monetary incentive delay task
Health group:Paired transcranial magnetic stimulation, monetary incentive delay task

Sponsors

Ningbo Kangning Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: ? A psychiatrist who understands and cooperates with this study was diagnosed as depression according to DSM-5 criteria; ? A psychiatrist evaluated the patients' pleasure loss symptom score = 28 points according to SHAPS; ? A psychiatrist assessed the dimension of patients' lack of pleasure according to TEPS; ? 17 Hamilton Depression Scale (HAMD-17) scores = 18; ? The score of the Brief Screening Scale for Dementia (BSSD) is>22, which is used to eliminate cognitive dysfunction; ? Right-handed, normal vision and vision; ? 18 to 50 years old; ? Junior high school education or above, able to complete the tasks and inspections necessary for research;

Exclusion criteria

Exclusion criteria: Exclusion criteria: ? excluding schizophrenia, bipolar disorder, severe depression with mental symptoms and other mental disorders; ? During pregnancy and breastfeeding; ? There are implanted metal objects in the body; ? With a history of brain injury; ? Accompanied by a history of addiction; ? Accompanied by other neurological diseases, such as epilepsy and dementia; ? There has been other physical therapy history (such as TMS or electric shock therapy) during the treatment of depression.

Design outcomes

Primary

MeasureTime frame
Temporal Experience of Pleasure Scale;Key capture accuracy;reaction time;

Secondary

MeasureTime frame
Hamilton Depression Scale 17item;Brief Screening Scale for Dementia;Snaith-Hamilton Pleasure Scale;gender;height;smoking;drinking;Education level;

Countries

China

Contacts

Public Contactmahong

Ningbo Kangning Hospital

mahongnbu@163.com+86 15728046957

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026