premature ovarian insufficiency
Conditions
Interventions
POI Group :N/A
Control group:N/A
Sponsors
Women’s Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: POI Group Inclusion Criteria: ? Females, aged 18-39, who visited outpatient clinics of participating units during the study period; ? Meet POI diagnostic criteria; ? Voluntary to participate in this study and willing to cooperate with the investigation and follow-up. Control group inclusion criteria: ? Age 18-40 years; ? According to the health examination report within 1 year, there are no obvious organic and functional diseases; ? Regular menstruation: cycle 21-35 days, menstrual period 3-7 days, no excessive or too little menstrual flow, no bleeding during menstruation; ? There is no early menopause (< 45 years of age) in first-degree relatives.
Exclusion criteria
Exclusion criteria: POI Group Exclusion Criteria: ? Complicated with reproductive endocrine diseases: such as polycystic ovary syndrome, functional hypothalamic amenorrhea, ovarian resistance syndrome,etc.; ? Those who are receiving cycle adjustment,HRT and other steroid hormone-containing drugs (such as contraceptives) now or within half a year; ? Chromosomal abnormalities,such as Turner syndrome; ? Those who intend to undergo assisted reproduction; ? Pregnant or lactating women; ? Uncontrolled endocrine system, cardiovascular system, autoimmune related diseases; ? Abnormal liver and kidney function, blood coagulation function and severe anemia; ? Malignant tumor, medical history of radiotherapy and chemotherapy; ? Mental illness or cognitive impairment; ? Persons without informed consent. Control exclusion criteria: ? Pregnancy, lactation, perimenopause and postmenopausal women; ? Uncontrolled endocrine system, cardiovascular system, autoimmune related diseases; ? Abnormal liver and kidney function, coagulation function and severe anemia; ? history of malignant tumors; ? history of psychiatric illness; ? Have a history of taking steroid-containing hormone-containing drugs (such as estrogen and contraceptives) within half a year; ? Family history of hereditary diseases; ? Those who have not given informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sex hormone test;Markers of bone turnover;Body fatcontent;Carotid intimal medial thickness (CIMT) ;Bone mass;Muscle mass;Brachial artery flow-mediated endothelial-dependent vasodilation (FMD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Thyroid function test;Ultrasound of uterus and breast; | — |
Countries
China
Contacts
Public ContactJianhong Zhou
Women’s Hospital, Zhejiang University School of Medicine
Outcome results
None listed