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Determination of EC90 of Ropivacaine for Intercostal Muscle Block of Pectoralis Major by Partial Coin Random Sequential Method

Determination of EC90 of Ropivacaine for Intercostal Muscle Block of Pectoralis Major by Partial Coin Random Sequential Method

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300069110
Enrollment
Unknown
Registered
2023-03-07
Start date
2022-11-20
Completion date
Unknown
Last updated
2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Surgery Patients

Interventions

Experimental group:Adjust local anesthetic concentration one by one

Sponsors

First Affiliated Hospital of Nanchang University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: ?Patients undergoing elective median thoracotomy cardiac surgery ?Age 18-65 ?ASA grade II-III ?Body mass index 18.5-24kg/m2

Exclusion criteria

Exclusion criteria: ?Allergic to local anesthetic ropivacaine ?Patient has a history of chronic neuropathic pain ?Patients with preoperative albumin 120U/L or ALT>120U/L ?The patient 's preoperative platelet 33.8S or PT>12.1S (33.8 and 12.1 are the reference intervals set by the clinical laboratory of our hospital according to the current normal control values of 25.2 and 10.9, respectively. If the normal control value changes, the reference interval will also change accordingly) ?Concurrent participation in other clinical trials ?Patients and their families refused to be enrolled in the trial

Design outcomes

Primary

MeasureTime frame
At 30 minutes after the block is completed, the patient's block plane is measured with ice and the effectiveness of the block is determined by whether the T2-T6 plane is covered.;

Secondary

MeasureTime frame
Vital signs;Symptoms of local anesthetic intoxication;Postoperative Opioid Use;Postoperative NRS score;Postoperative mechanical ventilation time;length of stay in the Intensive Care Unit;Postoperative length of hospital stay;Plasma ropivacaine concentration;

Countries

China

Contacts

Public Contactchenshibiao
ndyfy00763@ncu.edu.cn13870982918

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026