functional dyspepsia
Conditions
Interventions
High frequency stimulation group:transcutaneous vagus nerve stimulation(20HZ)
Low frequency stimulation group:transcutaneous vagus nerve stimulation(4HZ)
Healthy control group:N/A
Sponsors
Guang 'anmen Hospital, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for FD patients: (1) =18 years old, =65 years old; (2) Meeting the diagnostic criteria of Rome?; (3) No organic, systemic or metabolic diseases were found in routine examination (including gastrointestinal endoscopy); (4) no gastrointestinal motion-promoting drugs, such as cisapili and domperidone, were taken within 1 week before treatment; (5) To participate voluntarily and sign the informed consent. Note: Only patients meeting the above 6 conditions could be included in this study. Inclusion criteria for healthy subjects: (1) In good health without any obvious neurological, mental or medical conditions, especially cerebrovascular stroke, vascular dementia, depression or subclinical hypothyroidism; (2) =18 years old, =65 years old (3) no drug abuse; (4) No contraindications for MRI (claustrophobia with metal implants including pacemakers, metal joints, etc.).
Exclusion criteria
Exclusion criteria: Exclusion criteria for FD patients: (1) Refusing to sign the informed consent form; (2) Those who do not meet the Rome IV diagnostic criteria; Hp test is positive; (3) Dyspepsia caused by any serious or malignant disease, such as liver cirrhosis, heart failure or gastrointestinal tumor; (4) Take drugs that may affect dyspepsia recently, such as anti-secretory drugs, anti-acid drugs, anti-inflammatory drugs, non-steroidal anti-inflammatory drugs, etc; (5) Recently taking prokinetic drugs, such as anticholinergic drugs or dopaminergic drugs; (6) Recently taking anti-anxiety and antidepressant drugs, such as fluoxetine and escitalopram; (7) Patients who are not conscious, have a history of mental illness or are suffering from mental illness; (8) Diabetes, malignant tumor and other serious consumptive diseases; (9) Patients with cardiovascular and liver and kidney dysfunction; (10) Have a history of gastrointestinal surgery; (11) Planned pregnancy, pregnant women and nursing patients; (12) People who are allergic to skin contact; (13) Ear nail area with serious skin damage and absence of auricle; (14) Those with contraindications to MRI (implanted metal in the body, including cardiac pacemaker, metal joint, etc., claustrophobia). Note: Those who meet any of the above conditions will be excluded. Exclusion criteria for healthy subjects: (1) History of neurological and psychiatric diseases (2) Family history of neurological and psychiatric diseases; (3) Metal implants in the body (4) claustrophobia (5) Allergic constitution (6) Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall dyspepsia symptom score;Upper abdominal pain score;Hamilton Anxiety Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Nipine dyspepsia Quality of Life Index;Hamilton Depression Scale; | — |
Countries
China
Contacts
Public ContactJiliang Fang
Guang 'anmen Hospital, China Academy of Chinese Medical Sciences
Outcome results
None listed