breast cancer
Conditions
Interventions
Control Group:No
Remimazolam :R1 Group:Maintenance of anesthesia:Propofol+Remimazolam 0.1mg/kg/h
Remimazolam :R1 Group :Maintenance of anesthesia:Propofol+Remimazolam 0.3mg/kg/h
Sponsors
Department of Anesthesia, the first People's Hospital of Lianyungang
Eligibility
Sex/Gender
Female
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1)18= age < 65 years; 2)Selective radical operation for breast cancer, the operation time was less than 3 hours; 3)ASA :I-II; 4)18kg/m2 < BMI < 30kg/m2; 5)Patients have a clear understanding of the study and voluntarily participate in the study and have their informed consent .
Exclusion criteria
Exclusion criteria: 1) Patients who had severe anxiety and depression before operation, or who had been diagnosed with mental system disease and had a long-term history of taking psychotropic drugs; 2) Radical operation for bilateral breast cancer; 3) Patients with severe cardiac cerebrovascular disease, liver and renal dysfunction before operation; High-dose or long-term use of benzodiazepine, alcohol or sedatives within a week; 5) Having a history of epilepsy or a family history of epilepsy; 6) Allergic or contraindicated to any drug in the test; 7) Those who could not cooperate with the MMSE test before operation and whose scores were lower than their corresponding educational level (illiteracy =17 points, primary school =20 points, middle school =22 points, university =23 points) ; 8) Other conditions in which the researchers considered it inappropriate to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HADS scores of the first postoperative day; | — |
Secondary
| Measure | Time frame |
|---|---|
| HADS scores of before surgery and the first to three postoperative days;VAS and AIS scores of before surgery and the first to three postoperative days;HR, MBP, SPO2, BIS at baseline, intubation, skin incision, mastectomy, skin suture and extubation;The amount of vasoactive drugs used during operation;Incidence of clinical adverse events;Postoperative patient satisfaction scores; | — |
Countries
China
Contacts
Public ContactYong Wu
Nanjing Medical University, Department of Anesthesiology, Lianyungang School of Clinical Medicine
Outcome results
None listed