Obesity
Conditions
Interventions
A Group:the moumal salinegroup
B Group:Injection of 0.5 mg Penehyclidine before induction of anesthesia.
C Group:I.V 0.25mg Penehyclidine before anesthesia induction, and 0.25mg Penehyclidine was added to the postoperative intravenous analgesia pump.
Sponsors
The Second People's Hospital of Changzhou
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Patients have a strong desire for surgery, and the weight loss effect by diet and exercise is not ideal.2) Age from 18 to 65 years old, and received LSG for the first time. 3) BMI from 32 to 50. 4) ASA grade from ?to ?,and can tolerate general anesthesia and laparoscopic surgery.
Exclusion criteria
Exclusion criteria: 1). Glaucoma and prostate hypertrophy patients; 2). Allergic to Penehyclidine, atropine,or other anticholindrugs. 3). Antiemetic treatment within 12 hours before surgery; 4). History of schizophrenia, Parkinson's disease, deep dementia, or language disorder; 5). ASA is equal or greater than IV. 6). Patients with severe liver and kidney insufficiency; 7). Patients with a history of gastrointestinal diseases or surgery, or those who are breastfeeding during pregnancy; 8). Patients have poor compliance and cannot cooperate with preoperative preparation and postoperative rehabilitation guidance; 9). Patients considered unsuitable for participation according to the investigators judgment were also excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of the PONV; | — |
Countries
China
Contacts
Public ContactWu Zhouquan
The Second People's Hospital of Changzhou
Outcome results
None listed