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Effect of penehyclidine hydrochloride preconditioning on renal function after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Effect of penehyclidine hydrochloride preconditioning on renal function after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300069054
Enrollment
Unknown
Registered
2023-03-06
Start date
2023-03-06
Completion date
Unknown
Last updated
2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pseudomyxoma peritonei

Interventions

Control Group:The control group was given 3 ml of normal saline 10 minutes before induction
PHC Group:The PHC group was given intravenous PHC (diluted 0.01mg/Kg to 3ml) 10 minutes before induction

Sponsors

the Aerospace Center Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with pseudomyxoma peritonei and undergoing selective cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy 2.ASA grade I-III 3. Patients who consented to participate in this study and informed consent was obtained

Exclusion criteria

Exclusion criteria: 1. Preoperative renal insufficiency (KDOQI stage =4, eGFR<30mL/min/1.73m2) 2. History of abdominal surgery within the past 1 month 3. Glaucoma 4. Autoimmune disease with immunosuppressant or glucocorticoid therapy in the past 1 month 5. Taking the antioxidant ulinastatin and other drugs for the past week

Design outcomes

Primary

MeasureTime frame
creatinine;—

Secondary

MeasureTime frame
Neutrophil gelatinase-associated lipocalin;Kidney damage molecule-1;—

Countries

China

Contacts

Public ContactShuo Liu

the Aerospace Center Hospital

liushuo861113@163.com18618181589

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026