KOA
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. aged 18-60 years (>18.0 years at enrollment and <60.0 years at the end of the outgoing follow-up) 2. patients with early diagnosis of KOA in accordance with the Chinese Medical Association's Guidelines for the Treatment of Osteoarthritis, 2018 edition 3. unilateral knee onset and 3 points = VAS score = 6 points and HSS score = 59 points. 4. informed consent and signed informed consent form. 5. those who can be followed up and can describe the changes in their condition in more detail
Exclusion criteria
Exclusion criteria: 1. Patients with non-KOA knee pain as the main cause, and patients with chronic pain caused by other diseases. 2. Combined with serious diseases of the heart, brain, liver, kidney and hematopoietic system or abnormal liver and kidney function. 3. Patients with history of drug allergy (especially NSAID allergy), or allergic patients (allergic to more than 2 types of substances), or local skin allergy of lower extremities (especially allergic to topical drugs). 4. Pregnant, preparing for pregnancy or breastfeeding women, psychiatric patients, etc. 5. Those who have local skin lesions, infections or other topical drug treatments on the joints. 6. Patients who have participated or are participating in other clinical trials within the last 1 month. 7. Patients who, in the judgment of the investigator, have poor compliance and are unable to complete the experiment, or others who, in the judgment of the investigator, are not suitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual analog scale (VAS);Hospital for special surgery (HSS);EMG signal on the surface of the quadriceps muscle;Infrared thermal imaging temperature difference value; | — |
Countries
China
Contacts
The First Teaching Hospiital of Tianjin University of TCM