Heart valve disease, coronary heart disease
Conditions
Interventions
Group A:50% FiO2+conventional lung protective ventilation
Group B:50% FiO2+driving pressure-guided lung ventilation
Group C:80% FiO2+conventional lung protective ventilation
Group D:80% FiO2+driving pressure-guided lung ventilation
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Patients undergoing elective lower median open-heart surgery under cardiopulmonary bypass (2) Age 30-75 years old and gender unlimited; (3) ASA ? ~ IV grade; (4) NYHA? ~ ? grade; (5) Body mass index (BMI) of 18 ~ 28kg/m2
Exclusion criteria
Exclusion criteria: (1) Previous thoracic and pulmonary operations (2) Preoperative mechanical ventilation (3) Patients with severe respiratory diseases before surgery (such as asthma, chronic obstructive pulmonary disease, acute respiratory failure, etc.); (4) Severe abnormalities of liver, kidney and coagulation before surgery (ALT>100U/L,AST>100U/L, serum bilirubin >40µmol/L, serum albumin 353µmol/L, BUN>14.3mmol/L, PT >6 s, INR>2.3); (5) Intracranial hypertension and pneumothorax; (6) Minimally invasive surgery (thoracoscopic assistance, etc.);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation index;Pulmonary complications 7 days after surgery;Lung ultrasound score (LUS);Pulmonary complications 7 days after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Drive pressure (DP);Lung compliance; | — |
Countries
China
Contacts
Public ContactZhu Yunsheng
Department of Anesthesiology, the First Affiliated Hospital of Nanchang University
Outcome results
None listed