Nasopharyngeal carcinoma
Conditions
Interventions
Sponsors
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. The nasopharyngeal lesions were histopathologically diagnosed as undifferentiated non-keratoma (poorly differentiated squamous cell carcinoma); 2. Lesions located in the nasopharyngeal cavity (rT1), nostril or nasal septum (rT2a), superficial parapharyngeal space (rT2b), or the bottom wall of the sphenoid sinus (rT3) were defined as operatively resectable lesions according to the eighth edition of the AJCC; 3. At least 1 year from the end of radiotherapy; 4. Karnofsky scale (KPS) >=70; 5. Aged 18-70 years, no gender limit; 6. Willing to undergo surgery, able to provide informed consent and participate in regular follow-up; 7. No systemic treatment, such as chemotherapy, immunotherapy, etc.
Exclusion criteria
Exclusion criteria: 1. The recurrent disease has received salvage treatment; 2. Distant metastasis; 3. Extensive recurrent primary tumors beyond the resectable area, such as extensive invasion of the skull base or a distance of less than 0.5 cm from the tumor margin to the internal carotid artery; 4. Recurrence of unresectable lymph nodes, such as invasion of carotid sheath; 5. Initial grade 3 or worse; 6. Life-threatening diseases of liver, kidney, heart and other organs, abnormal coagulation function or bleeding tendency; 7. Neurological or psychiatric diseases; 8. Unwilling to sign informed consent or participate in this study; 9. Patients with poor compliance; 10. Patients with restricted mouth opening; 11. Pregnant and lactating patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3-year local recurrence free survival rate;The volume increase rate of affected nasal cavity 6 months after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| 3-year overall survival rate;3-year local recurrence free survival;3-year progression free survival;Surgical margin;Operation time;Epithelialization time of operative cavity;Quality of life;Incidence of complications; | — |
Countries
China
Contacts
Public ContactHuang Xiaoming
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Outcome results
None listed