Knee Osteoarthritis
Conditions
Interventions
MB group :Methylene blue combine with cocktail
Control group :Conventional cocktail
Sponsors
Affiliated Hospital of Panzhihua University
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >=50 years, ASA grade I-III; 2. Preoperative diagnosis of knee osteoarthritis; 3. Primary total knee replacement is planned; 4. Informed consent, the patient can independently complete the NRS score and has no mental illness.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to any ingredient in the ‘’cocktail’’ formula; 2. Severe cardiovascular and cerebrovascular diseases and respiratory diseases; 3. Use of opioids before surgery; 4. Patients taking anticoagulant or antiplatelet drugs before surgery; 5. Patients with active peptic ulcer and recent gastrointestinal bleeding; 6. Serious varus or valgus deformity of knee joint; 7. Any central or peripheral neuropathy; 8. Severe renal dysfunction (serum creatinine >200ummol/L); 9. Severe obesity, BMI>35kg/m^2; 10. Patients with hematological diseases, anemia, thrombocytopenia and coagulation disorders; 11. Patients with contraindications of subarachnoid anesthesia puncture.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numerical Rating Scale;The total consumption of sufentanil; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6;C-reactive protein, CRP; | — |
Countries
China
Contacts
Public ContactDeng Yijiang
Affiliated Hospital of Panzhihua University
Outcome results
None listed