Intraoperative hypotension
Conditions
Interventions
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged>40 years; 2. ASA classification II-III; 3. Plan to undergo elective non-cardiac surgery under general anesthesia; 4. Suffer from chronic hypertension and take ACEI/ARB drugs regularly for a long time (more than 6 months); 5. The way to take ACEI/ARB drugs is once every morning, and only take Class A antihypertensive drugs.
Exclusion criteria
Exclusion criteria: 1. Poor drug control of hypertension (SBP >= 160mmHg and/or DBP >= 100mmHg); 2. Secondary hypertension; 3. Patients taking ACEI/ARB drugs due to heart failure or chronic kidney disease; 4. Patients with previous cardiac and renal insufficiency; 5. Operations requiring controlled hypotension (such as hepatectomy, rotator cuff repair, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dosage of phenylephrine per hour during operation (µg/h); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of acute kidney injury by day 3 after surgery;Incidence of myocardial injury by day 3 after surgery;Incidence of hypertension when entering the operating room;Incidence of postoperative hypertension;Unplanned admission rate to ICU;Incidence of discontinuation of surgery due to high blood pressure;Incidence of cardiovascular and cerebrovascular adverse events during perioperative period;Length of hospital stay;All-cause mortality within 30 days after operation;The onset time of hypotension within 15 minutes after induction;Incidence of refractory hypotension during operation; | — |
Countries
China
Contacts
Public ContactLiu Su
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed