Perioperative depression
Conditions
Interventions
Low dose group:Esketamine+sufentanil+metoclopramide
Control group:Sufentanil+metoclopramide
Medium dose group:Esketamine+sufentanil+metoclopramide
High dose group:Esketamine+sufentanil+metoclopramide
Sponsors
The First Affiliated Hospital of Shihezi University Medical College
Eligibility
Sex/Gender
Female
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologists (ASA) grade ? to ?; 2. Aged 30 to 75 years; 3. BMI 18.5-28.0kg/m^2; 4. Understand the use of the scale and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to esketamine and other drugs used in this study; 2. Patients with mental illness and intellectual disability; 3. Patients with history of severe cardiovascular, kidney and liver diseases and cerebrovascular accidents; 4. Poorly controlled hypertension (=180/90mmHg), increased intracranial pressure, increased intraocular pressure (glaucoma), untreated or poorly controlled hyperthyroidism; 5. Severe anemia; 6. Refuse to participate in clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression Assessment Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Recovery Quality 15 Item Scale;Visual Analogue Scale, VAS;Occurrence of adverse reactions; | — |
Countries
China
Contacts
Public ContactGu Dengfeng
The First Affiliated Hospital of Shihezi University Medical College
Outcome results
None listed