major depressive disoder, bipolar disorder
Conditions
Interventions
Group A:True stimulation left DLPFC+LC treatment
Group B:True stimulation left DLPFC+false stimulation left LC treatment
Sponsors
First Affiliated Hospital of Ji'nan University
Eligibility
Sex/Gender
All
Age
10 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Aged 10-45 years, no gender limit; 2. Meet the DSM-5 criteria for major depressive disorder or bipolar disorder (type I or II) depressive episodes; 3. 24 Hamilton Depression Scale scores > 20 points, and item 3 > 2 points; 4. Score of Young's Mania Scale < 6; 5. The answer to question 4 (active suicidal ideation) or question 5 (passive suicidal ideation) of the Baker Suicide Ideation Scale is ‘’Yes’’; 6. Passed the TMS safety assessment questionnaire; 7. Han nationality, right-handed; 8. As the subject voluntarily, the patient himself or her legal guardian signs the informed consent.
Exclusion criteria
Exclusion criteria: 1. Other mental disorders along the comorbidity axis I; 2. Patients with a history of psychoactive substance abuse, alcohol abuse or dependence; 3. Patients with severe physical diseases and organic brain diseases; 4. Received electroconvulsive therapy or transcranial magnetic stimulation after onset of the disease; 5. Pregnant or lactating patients; 6. Those who cannot cooperate or have magnetic resonance examination taboo (such as heavy metal implants or wearing dentures or orthotics with teeth); 7. Failure to follow the research protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Beck Scale for Suicide Ideation;Columbia Suicide Severity Rating Scale;MATRICS Consensus Cognitive Battery, MCCB;Das-Naglieri: Cognitive Assessment System, DN:CAS;NAA/Cr ratios of prefrontal cortex;NAA/Cr ratios of basal ganglia;NAA/Cr ratios of cerebellum;mI/Cr ratios of prefrontal cortex;mI/Cr ratios of basal ganglia;mI/Cr ratios of cerebellum;Cho/Cr ratios of prefrontal cortex;Cho/Cr ratios of basal ganglia;Cho/Cr ratios of cerebellum;Brain volume and cortex;Functional connection of brain;Stroop Color-Word Test;Wsiconsin Card Sorting Test, WCST;Trail Making Test-part B, TMT-B; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale;Young Mania Rating Scale;Hamilton Rating Scale for Anxiety;Beck Hopelessness Scale;Montgomery-Asberg Depression Rating Scale;Near-infrared spectroscopy; | — |
Countries
China
Contacts
Public ContactJia Yanbin
First Affiliated Hospital of Ji'nan University
Outcome results
None listed