Adenomyosis, infertility
Conditions
Interventions
Group A:GnRH-a pretreatment + fresh embryo transfer protocol
Group B:Whole embryo freezing + GnRH-a pretreatment + FET protocol
Sponsors
Shanghai First Maternity and Infant Hospital
Eligibility
Sex/Gender
Female
Age
25 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Aged 25-40 years; 2. Basal antral follicles >=5, or AMH >=1.2 ng/L; 3. Clinical diagnosis of uterine adenomyosis, in line with IVF indications, including tubal factors, ovulation disorders, endometriosis, 3 failed artificial inseminations, and male factors; 4. Diagnosis of adenomyosis: According to the consensus of Chinese experts on the diagnosis and treatment of adenomyosis with infertility in 2021, it is recommended to use the TVUS imaging-based diagnosis of adenomyosis developed by the Collaborative Group of Morphological Uterus Sonographic Assessment authorized by the International Federation of Gynecology and Obstetrics in 2018. A total of 8 ultrasound features are: asymmetric myometrial thickening; myometrial cystic foci; island hyperechoic signal; fan-shaped shadow; subendometrial linear or punctate echo; there are strips of blood flow signals passing through the lesion; the binding band is irregular in shape; the binding band is discontinuous, and the evaluation of the binding band is recommended to be confirmed by 3D-TYUS examination. If two or more of the above-mentioned signs are present on ultrasonography, adenomyosis is suspected.
Exclusion criteria
Exclusion criteria: 1. Systemic diseases of the whole body; 2. Pre-implantation embryo genetic diagnosis cycle, ovulation donation cycle, ovulation freezing cycle, sperm donation cycle; 3. Hyperprolactinemia, ovarian tumor, uterine malformations (dual uterus, mediastinal uterus, etc.); 4. Patients with hydrosalpinx or untreated endometrial polyps; 5. Patients with acute and chronic genital tract tumors, genital tract inflammation and other diseases that are not suitable for promoting ovulation; 6. Patients who have taken hormone therapy within the last 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Carbohydrate antigen CA125;Clinical pregnancy rate;Cumulative live birth rate from one cycle of ovarian stimulation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy complications;Miscarriage rate;Embryo implantation rate;Number of mature eggs;Normal fertilization;Number of embryos available;Uterine size;Adenomyosis lesion size;Number of eggs retrieved; | — |
Countries
China
Contacts
Public ContactAi Ai
Shanghai First Maternity and Infant Hospital
Outcome results
None listed