primary hyperaldosteronism
Conditions
Interventions
Index test:18F-AlF-NOTA-pentiaxther PET/CT
Sponsors
Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Persistent hypertension or refractory hypertension with blood pressure >160/100 mmHg (blood pressure >140/90 mmHg, combined with three antihypertensive drugs, including diuretics) and hypokalemia. 2. Uncontrolled hypokalemia with or without hypertension. 3. Persistent hypertension or refractory hypertension with blood pressure >160/100mmHg, aldosterone-renin ratio (ARR) >=30 (ng/dl)/(ng/ml/h). 4. A positive captopril test (<=30% reduction in plasma aldosterone levels after captopril administration) is a sufficient but not mandatory condition. 5. Patients whose CT showed unilateral or bilateral adrenal nodules with clear boundaries but normal serum potassium and ARR<30 (ng/dl)/(ng/ml/h) were also included in the study.
Exclusion criteria
Exclusion criteria: 1. Female patients who are pregnant (or pregnant within half a year), breastfeeding or do not want to take contraceptive measures; 2. Abnormal cardiopulmonary function or mental state, unable to tolerate prone lying for 20 minutes; 3. Refused to sign a consent form or unable or unwilling to comply with the approved by the researchers study plan; 4. Other conditions not considered suitable for participation in the study by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Standardized uptake;Accuracy, specificity, sensitivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lesion size; | — |
Countries
China
Contacts
Public ContactZhang Wei
Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital
Outcome results
None listed