Prevalence of Primary Progressive Aphasia in Younger Onset Dementia and Effectiveness of a Speech Therapy on Improving Lexical Retrieval and Reducing Caregiving Burden

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300068920

Enrollment

Unknown

Registered

2023-03-01

Start date

2023-03-01

Completion date

Unknown

Last updated

2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dementia

Interventions

Group of primary progressive aphasia:Speech therapy

Eligibility

Sex/Gender

All

Age

40 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Participants for prevalence study (n=250): (1) Diagnosis of younger onset dementia by specialists or general practitioners; (2) Aged between 40 – 65 years. 2. Participants with positive PPA (n=83): (1) Diagnosis of younger onset dementia by specialists or general practitioners; (2) Native Cantonese speaker, speaking Cantonese for more than 10 years for 60% of daily communication before joining the proposed study; (3) Aged between 40 – 65 years; (4) Received at least 6 years of formal education; (5) Diagnosis of possible positive primary progressive aphasia (PPA) by failing at least one subtest in the Chinese Language Assessment in Primary Progressive Aphasia (CLAP) for group intervention. 3. Participants with roles of Caregivers of participants with dementia with possible positive PPA for group intervention (n=83). 4. Participants who are Healthcare workers providing services for elderly or people with cognitive impairment for group intervention (participation for knowledge transfer purpose) (n=20).

Exclusion criteria

Exclusion criteria: 1. Concomitant major brain disease (including but not limited to CVA, PD, brain tumour, or TBI). 2. Hearing levels > 35 dB HL/ dB SPL on both ears (not fitted with hearing aids). 3. Visual acuity worse than 6/12 to 6/18. Moderate –visual acuity worse than 6/18 to 6/60 (not corrected by lens). 4. No verbal language output (mute). 5. History of learning disabilities or pediatric development disorders including but not limited to autism spectrum disorders/pervasive childhood developmental disorders, Aspergers syndrome, ADHD, or Downs syndrome.

Design outcomes

Primary

Measure	Time frame
accuracy of lexical retrieval;	—

Countries

China

Contacts

Public ContactProfessor Timothy KWOK

Department of Medicine and Therapeutics, Faculty of Medicine, the Chinese University of Hong Kong

tkwok@cuhk.edu.hk+852 35053145

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026