Chronic musculoskeletal pain (stasis, cold and wet obstruction)
Conditions
Interventions
Experimental group:Tongluo analgesic cream intervention
Positive control group:Loxoprofen sodium patch intervention
Placebo control group:Pathway analgesic cream mimicry/loxoprofen sodium patch mimicry intervention
Sponsors
Gansu Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria for chronic musculoskeletal pain, and the differentiation is stasis stasis, cold and wet obstruction. If it is chronic low back pain, it must meet the diagnostic criteria of the American Physical Therapy Association for chronic low back pain and the course of the disease must be greater than or equal to half a year; (2) local pain as the main complaint, and 4 points<= current pain VAS score of a single site <= 8 points; (3) 18-65 years old, male or female, junior high school education level or above, clear understanding and expression ability; (4) The subject signs the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Chronic musculoskeletal pain secondary to infectious inflammation, Parkinson's disease, multiple sclerosis or unknown etiology; Patients with fibromyalgia; Patients with variable or frequent pain location; Chronic musculoskeletal pain due to structural changes that meet the indications for surgery; Chronic post-traumatic limb pain and chronic neuropathic limb pain; Patients who have had multiple previous treatment failures due to lack of efficacy or poor tolerability; (2) The onset of pain lasts for more than 3 days; or the pain has been significantly reduced since the onset of this pain; (3) Those who have received analgesics, nonsteroidal anti-inflammatory drugs, misoprostol, antidepressants or quinolone antibacterial agents within 1 week; (4) Consult those with a history of hypertension, heart failure, anemia, bronchial asthma, peptic ulcer, ulcerative colitis, Crohn's disease and so on; (5) Consult those with other serious primary cardiovascular diseases, liver diseases (such as previous history of liver function exceeding the upper limit of normal value), renal lesions (such as previous history of renal function Cr exceeding the upper limit of normal value), hematological lesions, lung diseases, digestive tract lesions or serious diseases affecting their survival; Those with tumors, tuberculosis and other diseases; (6) Those who have broken or abnormal skin (such as rash, eczema, after surgery, etc.) at the application site, allergic skin; (7) Consult women who are breastfeeding, pregnant or preparing for pregnancy within half a year; (8) Those who have a history of drug patch substrate and drug allergy, or allergic constitution (those who are allergic to more than 2 types of substances). Those who have previously induced asthma, urticaria or allergic reactions after taking aspirin or other nonsteroidal anti-inflammatory drugs; (9) Those who have participated in other clinical trials within 3 months of the consultation; (10) Have circumstances that the investigator believes are not suitable for participating in the research, such as the motor state or working state that may aggravate the pain.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue scoring;ID pain scale;Concise Pain Assessment Scale;Concise McGill Pain Questionnaire;Improved Barthel Index (MBI) score;ODI index; | — |
Countries
China
Contacts
Public ContactDeng Qiang
Gansu Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed