Anesthetic drugs are used in painless abortion
Conditions
Interventions
E1 group:Propofol + Esketamine 0.1mg/kg
E2 group:Propofol + Esketamine 0.15mg/kg
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective painless abortion, ASAI-II grade 2. Age 18-45 3. BMI 18.5-24 kg/m2 4. No obvious cardiopulmonary disease 5. Normal communication 6. Volunteers and sign informed consent
Exclusion criteria
Exclusion criteria: (1) Severe respiratory and circulatory diseases, such as severe coronary atherosclerosis Sclerosis, heart failure, myocardial infarction, respiratory failure and other underlying diseases (2) neurological diseases: such as severe cerebral hemorrhage or sequelae of cerebral infarction, hemiplegia, aphasia (3) mental illness: such as schizophrenia, depression and so on (4) Long-term drug abuse: including chemotherapy drugs, analgesics, etc (5) Complicated with obvious abnormal liver and kidney function (6) Patients with possible difficult airway, high intracranial pressure and high intraocular pressure (7) Patients allergic to anesthetic drugs such as propofol and esketamine (8) History of vaginal delivery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Propofol ED50;Incidence of respiratory depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure, heart rate, pulse oxygen saturation;The propofol injection hurts;Propofol initial dose maintenance time;BPS-NI score;Recovery time;Total amount of propofol;Retention time of PACU;Adverse reaction;VAS score; | — |
Countries
China
Contacts
Public ContactXuesheng Liu
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed