Neuronavigation iTBS of the precuneus enhances episodic memory and neural network mechanism in amnestic mild cognitive impairment

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300068811

Enrollment

Unknown

Registered

2023-03-01

Start date

2023-03-01

Completion date

Unknown

Last updated

2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

amnestic mild cognitive impairment

Interventions

iTBS treatment group:intermittent theta burst stimulation

iTBS sham treatment group:intermittent theta burst stimulation-sham stimulation

healthy control group:None

Eligibility

Sex/Gender

All

Age

55 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Inclusion criteria of MCI group: referring to the "core clinical criteria" of MCI in NIA-AA in 2011: 1) There were complaints of memory impairment. 2) Objective episodic memory function impairment (AVLT-20 minute delayed recall is lower than the corresponding norm). 3) The overall cognitive function was normal (MMSE>=24, MDS-2 >120), clinical dementia scale (CDR) =0.5. 4) Daily life can be independent (ADL=26, MDS-2 >120, ADL normal, HAMD<=7, HIS<=4. 4) The multidimensional cognitive neuropsychological assessment scale was within the normal range of age and education level matching.

Exclusion criteria

Exclusion criteria: 1. History of consciousness disturbance. 2. Family history of hereditary disease. 3. Central nervous system infection, cranial injury, epilepsy, multiple sclerosis, toxic metabolic diseases, Parkinson's disease, intracranial tumors, hypothyroidism, diabetes and other physical diseases. 4. History of mental illness such as schizophrenia and personality change. 5. had a depressive episode or HAMD score >=8. 6. A history of alcohol/drug dependence,or taking cognitive-improving medications. 7.Severe diseases of heart, liver, kidney, brain and hematopoietic system. 8. Clinical stroke or history of stroke: head MRI or CT in the diameter of the lesion >=2mm (if there is imaging evidence of subcortical, periventricular and deep brain infarction, but no symptoms and corresponding history of the patient is excluded), Hachinski ischemia score >4 points. 9. MRI scans and rTMS for the treatment of contraindications with implantation of electronic and metal devices.

Design outcomes

Primary

Measure	Time frame
Cognitive function;neural networks;	—

Countries

China

Contacts

Public ContactGao Lijuan

Affiliated ZhongDa Hospital, Southeast University

gaolijuan199007@163.com+86 15150534142

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026