Intervention study of virtual reality-based exercise and exercise in overweight and obese adolescents

Conditions

overweight and obesity

Wang J, Qin Y, Wu Q, Zeng D, Gao X, Wang Q, Li Z, Ni Y, Li H, Zhang P, Guo J, Ma W, Maitusun M, Jin X, Chen M, Zhu L, Lu Q, Chen Q, Wu Y, Lin C, Han R, Cheng D, Ni J, Wang X, Yao F, Zhuang J, Xia J, Liu D, Lu Y, Kang P, Yu S, Chen A, Zhang Y, Li Q, Ge W, Long X, Jiang Z, Guan Z, Jin Z, Jin P, Li T, Shu J, Yang J, Wang J, Jiang N, Qian J, Jung Y, Zhang H, Yang Q, Ma L, Wu X, Huang X, Si D, Ren J, Qiao H, Guo Y, Huang Z, Wang W, Deng W, Bi L, Zhao D, Li Y, Lau RWH, Tham YC, Ma X, Ma J, Shen D, Zhang S, Guan H, Zou W, Guo M, Guan X, Yang X, Xu A, Wu J, Panagiotou G, Tse MA, Kim J, Wu E, Thalmann D, Thalmann NM, Fregni F, Wong TY, Jia W, Zeng R, Lim CT, Sheng B, Li H.

2025-06-234 citations

10.1038/s41591-025-03724-5

Effect of virtual reality-based exercise and physical exercise on adolescents with overweight and obesity: study protocol for a randomised controlled trial

Qian Wu, Rui Han, Zhen Li, Xiao‐Jun Huang, Di Cheng et al. (30 authors)

BMJ Open2023-10-0112 citations

10.1136/bmjopen-2023-075332

Interventions

VR soccer group:Added VR soccer training on the basis of the original on-campus physical education class

VR table tennis group:Added VR table tennis training on the basis of the original on-campus physical education classing

Real-world soccer group:Added real world soccer training on the basis of the original on-campus physical education classing

Real-world table tennis group:Added real world table tennis training on the basis of the original on-campus physical education classing

Control group:Maintain the original lifestyle (only on-campus physical education classing)

Eligibility

Sex/Gender

All

Age

11 Years to 18 Years

Inclusion criteria

Inclusion criteria: (1) Informed consent of parents and individuals (2) Between 11 and 18 years old (3) Overweight and/or obesity (4) Currently not taking weight-loss drugs and no previous history of bariatric drug use (5) Stable weight (self-reported weight change<5 kg) within 90 days before the screening period

Exclusion criteria

Exclusion criteria: (1) Participate in an organized weight loss program within 90 days before the screening period (2) Currently taking any of the following medications: pramlintide, orlistat, zonisamide, topiramate, lorcaserin, phentermine, bupropion, naltrexone, glucagon-like peptide-1 (GLP-1) receptor agonist, or metformin (used to treat obesity) (3) Have received previous surgical treatment for obesity (4) Damage to tissues and organs such as muscles, bones or nerves (hindering sports training) (5) Non-simple obesity, including endocrine and metabolic diseases (such as Cushing's syndrome, hypothyroidism, hypogonadism, polycystic ovary syndrome, etc.), tumors and trauma (6) History of severe mental illness (such as schizophrenia, bipolar disorder, major depression). (7) Confirmed subjects with bulimia nervosa disorder (8) People who have barriers such as vertigo when using VR (9) Any circumstance which may endanger the safety of the subject or the subject's non-compliance with the protocol

Design outcomes

Primary

Measure	Time frame
Change in body fat mass;	—

Secondary

Measure	Time frame
Change in body composition;Change in anthropometric indicators;Change in insulin sensitivity;Change in HbA1c;Change in cardiac autonomic neuropathy;Change in exercise-related indicators;Change in appetite;Change in cognitive function;Change in metagenomics;Change in metabolomics;Change in clinical biochemical indexes;Change in intrahepatic triglyceride content;Change in exercise-related indicators;Change in diopter;Changes in the fundus;Changes in the vision;Changes in the olfaction;	—

Measure

Time frame

Change in body composition;Change in anthropometric indicators;Change in insulin sensitivity;Change in HbA1c;Change in cardiac autonomic neuropathy;Change in exercise-related indicators;Change in appetite;Change in cognitive function;Change in metagenomics;Change in metabolomics;Change in clinical biochemical indexes;Change in intrahepatic triglyceride content;Change in exercise-related indicators;Change in diopter;Changes in the fundus;Changes in the vision;Changes in the olfaction;

—

Countries

China

Contacts

Public ContactLi Huating

Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

huarting99@sjtu.edu.cn+86 13916502465

Outcome results

None listed