Acute pancreatitis
Conditions
Interventions
Test group:5% albumin+ lactate Ringer's solution
Control group:lactated Ringer's solution
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) In accordance with the diagnostic criteria of acute pancreatitis in 2012 revision of the Atlanta classification 2) = 72 hours from onset to admission 3) The age is 18-75 years old, regardless of gender 4) Stay in ICU and SIRS = 2 points 5) Willing to follow the research procedure and sign the informed consent form
Exclusion criteria
Exclusion criteria: 1) Have serious allergy to human serum albumin and refuse to accept blood products; 2) Meet the inclusion criteria for more than 24 hours; 3) Albumin or other colloids (such as gelatin) have been infused before the onset of the disease; 4) Pregnant or lactating women; 5) Have suffered from serious cardiovascular, respiratory, liver, kidney, blood and immune diseases, which can be defined as: NYHA grade of cardiac function>grade II; active myocardial ischemia; cardiovascular interventions in the past 60 days; cirrhosis; chronic kidney disease with creatinine clearance<40ml/min or chronic obstructive disease requiring home oxygen therapy. 6) Active bleeding and/or hemoglobin level<70g/L; 7) Patients who have severe respiratory failure, systemic circulatory failure, coma or other irreversible dangerous manifestations and are expected to die within 24 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Day 3 SIRS mitigation rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Resuscitation and hemodynamic parameters;All cause mortality within 28 days;Ventilator free and days alive at 28 days;Days free of renal replacement therapy and alive at 28 days;Days free of vasoactive drugs and alive at 28 days;Incidence of bleeding events;Incidence of gastrointestinal perforation and fistula; | — |
Countries
China
Contacts
Public ContactLiang Xia
The First Affiliated Hospital of Nanchang University
Outcome results
None listed