Inflammatory bowel disease, irritable bowel syndrome.
Conditions
Interventions
Treatment group:transcutaneous vagus nerve stimulation
Sham-Stiming Group:sham-taVNS
Control Group:no
Sponsors
The People's Hospital of Guangxi Autonomous Region
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: a. age 18 to 65 years b. meet diagnostic criteria for inflammatory bowel disease and irritable bowel syndrome; c. right hand; d. Drugs that can be discontinued for gastrointestinal disorders in the first week of the study.
Exclusion criteria
Exclusion criteria: a. Severe comorbidities (e.g., uncontrolled hypertension or gastrointestinal bleeding, severe cardiopulmonary and encephalopathy) and coronary heart disease; b. autoimmune diseases affecting gastrointestinal motility, such as scleroderma and dermatomyositis; c. history of gastrointestinal surgery; d. Organic lesions of the stomach and intestines of any grade such as peptic ulcers and gastric tumors; e. presence of infectious lesions such as non-inflammatory bowel diseases such as enteric tuberculosis; f. Other functional gastrointestinal disorders are present; g. taking drugs for gastrointestinal disorders, drugs that affect GI motility, or drugs that cannot be withdrawn within 1 week before recruitment; h. unable to cooperate with the appropriate assessment and examination; i. Contraindications to magnetic resonance imaging (e.g., failure to remove metal dentures or other metal implants, claustrophobia, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IBS-SSS;QOL;Stool Characteristics Score;Structural Magnetic Resonance Imaging;DTI;fMRI;MRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| HAMD;HAMA;PHQ-9;GAD-7;PSQI; | — |
Countries
China
Contacts
Public ContactBei Peng
The People's Hospital of Guangxi Autonomous Region
Outcome results
None listed