Multimodal analgesia of pain after abdominal surgery in children
Conditions
Interventions
Group T:10min after induction of anesthesia, 1mg/kg tramadol hydrochloride was injected intravenously
Group TE:10min after induction of anesthesia, 1mg/kg tramadol hydrochloride and ESPB were injected intravenously
Group C:No drugs or nerve blocks were administered
Sponsors
Nanjing Maternal and Child Health Hospital
Eligibility
Sex/Gender
All
Age
5 Years to 12 Years
Inclusion criteria
Inclusion criteria: The American Society of Anesthesiologists (ASA) score was grade I to II, with 5 < 12 years of age, 15 < 30kg of body weight, and 0.5 ~ 2.0h of surgery.
Exclusion criteria
Exclusion criteria: 1. Children with absolute contraindications to single-cavity tracheal intubation and malignant hyperthermia susceptibility;2. Children with heart, lung, liver and kidney insufficiency;3. Children with severe infection, dehydration, electrolyte disturbance and shock;4. Children with neuromuscular system diseases;5. Infection and scar 2 to 4cm apart from the median line of the spine of T12-L3;6. Allergic history of amides local anesthetics and central analgesics;7. Chronic pain history, long-term use of various analgesics, severe brain injury, confusion, respiratory depression;8. People who are using monoamine oxidase inhibitors, or who are prone to drug abuse or dependence;9. Children who had participated in other clinical trials or were participating in other clinical trials within 3 months before enrollment;10. Children who, in the judgment of the physician responsible for the study, may be at increased risk for the subject or may not have adequate data from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IL-1ß protein concentration;TNF-a protein concentration;IL-4 protein concentration;IL-10 protein concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;Heart rate; | — |
Countries
China
Contacts
Public ContactHuiying Zhang
Nanjing Maternal and Child Health Hospital
Outcome results
None listed