Carotid atherosclerotic plaque
Conditions
Interventions
Intervention group:Neixiao Ruanmai Decoction
Control group:Neixiao Ruanmai Placebo
Sponsors
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients with carotid atherosclerotic plaque diagnosed by color Doppler ultrasound; 2. Patients aged from 40 to 65 years, regardless of gender; 3. Patients with lumen stenosis less than 70%; 4. Patients who can take medicine for a long time; 5. Patients with informed consent and those who signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with acute cardiovascular and cerebrovascular diseases; 2. Patients with previous history of cerebral hemorrhage; 3. Patients with active ulcer and bleeding tendency, long-term use of anticoagulant drugs (such as warfarin); 4. Patients with severe arrhythmia, atrial fibrillation and heart failure; 5. Patients with severe primary diseases such as liver, kidney, hematopoietic system, endocrine system and respiratory system, whose liver function is more than 1.5 times higher than the upper limit of normal value, and Cr is higher than the normal value; 6. Pregnant or lactating women, women with pregnancy plans in the near future; 7. Patients with allergic constitution; 8. Patients who are taking lipid-lowering medications 9. Patients who are taking dual antiplatelet drugs; 10. Any other life-threatening or serious disease that cannot be treated for 12 months will affect the evaluation results; 11. Other diseases or mental disorders that researchers believe may limit efficacy evaluation or patient follow-up; 12. Pacemaker implantation, metallic foreign bodies in the body, claustrophobia and seizures are contraindicated by MRI; 13. Patients who have participated in clinical trials of other drugs in recent 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total plaque volume; | — |
Secondary
| Measure | Time frame |
|---|---|
| Stenosis rate;Intima media thickness;Plaque thickness reduction;Percentage decrease in plaque thickness (cross section);Plaque area decline;Percentage of plaque area decrease (longitudinal section);blood lipids;blood pressure;hs-CRP;SAA; | — |
Countries
China
Contacts
Public ContactShengxian Wu
Dongzhimen Hospital of Beijing University of traditional Chinese Medicine
Outcome results
None listed