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Correlation between polymorphisms of the NR3C1 gene and clinical phenotype and efficacy of glucocorticoid in neonates with hypotension

Correlation between polymorphisms of the NR3C1 gene and clinical phenotype and efficacy of glucocorticoid in neonates with hypotension

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300068758
Enrollment
Unknown
Registered
2023-02-28
Start date
2023-03-01
Completion date
Unknown
Last updated
2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

neonatal hypotension

Interventions

Refractory group:Vasoactive inotrope score =60
Non refractory group:Vasoactive inotrope score <60

Sponsors

GuangDong Women And Children Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: All infants are diagnosed with neonatal hypotension.

Exclusion criteria

Exclusion criteria: (1) Infants whose legal guardian's disagreed to join or withdraw midway; (2) Congenital cardiac malformation(except non-hemodynamically significant patent ductus arteriosus and patent foramen ovale); (3) Chromosomal abnormalities, and suspected metabolic disorders; (4) Congenital diaphragmatic hernia; (5) Twin-to-twin transfusion syndrome.

Design outcomes

Primary

MeasureTime frame
Hypotension-related mortality;All-cause mortality within 28 days;Severe brain injury;—

Secondary

MeasureTime frame
Total glucocorticoid cumulative dose;—

Countries

China

Contacts

Public ContactZhongJunjuan

GuangDong Women And Children Hospital

zhong_junjuan@sina.com18617353765

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026