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Transcriptomics- and metabolomics-based exploration of the biological characteristics of Qi deficiency and blood stasis in heart failure with preserved ejection fraction

Transcriptomics- and metabolomics-based exploration of the biological characteristics of Qi deficiency and blood stasis in heart failure with preserved ejection fraction

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300068752
Enrollment
Unknown
Registered
2023-02-28
Start date
2022-07-01
Completion date
Unknown
Last updated
2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure with preserved ejection fraction

Interventions

HFpEF patients group:None

Sponsors

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. In accordance with the HFpEF diagnostic criteria of qi deficiency and blood stasis syndrome. 2. Age = 40 years. 3. Patients who receive standard drug treatment for heart failure and are currently in stable condition. 4. Those who voluntarily participate and have signed an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Patients with acute coronary syndrome. 2. Congenital heart disease, severe valvular heart disease, constrictive pericarditis, hypertrophic cardiomyopathy, limited (invasive) cardiomyopathy, etc. 3. Patients with a history of stent implantation and coronary artery bypass grafting in the past 90 days. 4. Patients who have been implanted with permanent pacemakers, implantable defibrillators or left ventricular assist devices in the past 90 days. 5. Systolic blood pressure (SBP) > 160mmHg or < 90mmHg when selected. 6. Patients with chronic lung disease who need oxygen therapy or drug intervention. 7. The death of cerebral infarction occurred in the past 90 days. 8. Patients with other diseases (such as severe failure of important organs such as liver and kidney, malignant tumor, etc.) need special treatment during treatment, which affect the clinical treatment of heart failure. 9. During pregnancy, lactation, or women of childbearing age but do not use reliable contraceptive methods. 10. The researchers judged that the patients had poor compliance and were unable to complete the trial. 11. Those who have participated in other clinical trials in the past 2 months (the hospitalized patients are calculated according to the time of admission).

Design outcomes

Primary

MeasureTime frame
Peripheral blood biomarkers;

Countries

China

Contacts

Public ContactGuanwei Fan
guanwei.fan@tjutcm.edu.cn13752503396

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026