Haemophilia orthopaedic disorders
Conditions
Interventions
Experimental Group:perioperative continuous infusion
Control Group:perioperative bolus infusions
Sponsors
Nanfang Hospital,Southern Medical University
Eligibility
Sex/Gender
All
Age
12 Years to 66 Years
Inclusion criteria
Inclusion criteria: ? Treated patients who plan to undergo elective surgery and are diagnosed with hemophilia A; ?Age 12-66 years old; ? Negative inhibitors (less than 0.6 BU/mL) and no positive history of inhibitors; ? Exposure days > 100 days; ? HIV negative, if HIV positive, CD4 lymphocytes should be >200/µl, and the viral load should be <200 grains/µl or <400,000 copies/ml; ?The subjects or their representatives have the ability to sign the informed consent.
Exclusion criteria
Exclusion criteria: ?Patients who are known or suspected to be allergic to Anjiain, including those allergic to hamster protein or related products; ? Positive inhibitors or a history of positive inhibitors; ?Patients with other congenital or acquired coagulation disorders; ? Those with a history of deep vein thrombosis, pulmonary embolism, acute myocardial ischemia and disseminated intravascular coagulation; ?Participated in other clinical trials 30 days before enrollment; ? Severe complications (such as severe liver and kidney disease, cardiac insufficiency, NYHA grade III and above) or conditions that the investigator believes may cause potential harm to the patient and interfere with the implementation of the study and the results of the study; ?Do not agree to sign the informed consent form; ? Behavioral or cognitive impairment and alcohol, drug addicts.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of surgical hemostasis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Perioperative changes in hemoglobin;Perioperative changes in hematocrit;perioperative blood transfusion;Perioperative blood loss;Perioperative coagulation factor dosage;Coagulation factor activity level;Hemophilia Joint Health Scale;EQ-5D; | — |
Countries
China
Contacts
Public ContactChen Bin
Nanfang Hospital,Southern Medical University
Outcome results
None listed