Effect of vitamin C on pain and inflammatory responses after total hip arthroplasty: a prospective randomized controlled study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300068723

Enrollment

Unknown

Registered

2023-02-28

Start date

2023-02-28

Completion date

Unknown

Last updated

2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hip osteoarthritis

Interventions

Control:none

vitamin C group:Perioperative vitamin C use

corticosteroid group:Perioperative corticosteroid use

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Patients with end-stage osteoarthritis of the hip planned to undergo total hip arthroplasty at the Department of Bone and Joint Surgery in our hospital.

Exclusion criteria

Exclusion criteria: (1) Elevated inflammatory indicators in preoperative examination; (2) Preoperative hemoglobin level <110 g/L or abnormal coagulation; (3) Developmental dysplasia of the hip with Crowe type III and type IV; (4) Hip joint Severe deformity, stiff or ankylosing hip; (5) autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, etc.; (6) patients with kidney stones.

Design outcomes

Primary

Measure	Time frame
visual analogue scale;Cumulative use of morphine;C-reaction protein;IL-6;ESR;	—

Secondary

Measure	Time frame
Harris scale;perioperative blood loss;Hip range of motion and circumference;Imaging assessment of thigh and buttock muscle volume;	—

Countries

China

Contacts

Public ContactHuang Qiang

Sichuan University West China hospital

huangqiang4325@126.com18980606708

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026