Influenza
Conditions
Interventions
control group:Jiebianqingli simulant+oseltamivir capsule
Experimental group:Jiebiaoqingli granules+oseltamivir simulant
Sponsors
China-japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Consistent with the clinical diagnosis of influenza (2) The results of influenza rapid antigen test were positive (3) 24 hours before admission, 37.5?= body temperature (armpit) < 39? (4) Within 48 hours from the onset of influenza symptoms to the first visit to the doctor (5) TCM syndrome differentiation is syndrome of exterior cold and interior heat (6) Age range from 18 to 65 years old (including 18 and 65 years old), gender is not limited (7) Voluntarily participate in this clinical trial and sign a written informed consent.
Exclusion criteria
Exclusion criteria: (1) Clinically diagnosed as severe or critical influenza (2) Total white blood cell count > 10.0×109/L, or neutrophil percentage > 80%, or purulent sputum symptoms, suspected bacterial infection (3) Other types of respiratory tract infections include acute rhinitis, sinusitis, tracheo-bronchitis, and pneumonia (4) with chronic respiratory diseases (such as COPD), cardiovascular diseases (such as coronary heart disease, myocarditis, etc.), Not including hypertension with stable blood pressure control, asymptomatic old lacunar infarction), kidney disease, liver disease, hematological diseases, nervous system and neuromuscular diseases, metabolic and endocrine system diseases (such as diabetes), immune suppression (including immunosuppressant use or HIV infection caused by immune dysfunction) (5) Liver function (ALT, AST = 2 times of normal value) and renal function abnormalities (SCR> normal value) (6) BMI greater than 30[BMI= weight (kg)/ height (m)2] (7) During the course of the disease, the patients received antiviral drugs before randomization (8) Have received influenza vaccine in the last year (9) Allergic disease (such as allergic rhinitis, allergic asthma, etc.), or allergy to test drugs, including a history of allergy to the ingredients, acetaminophen or drug excipients (10) Women who are pregnant or plan to have a pregnancy in the next 3 months, breastfeeding women; Women of childbearing age who are unable or unwilling to use adequate contraception during the trial or within one month after the last dose of medication, or their spouses who do not want to use contraception (11) Unable or unwilling to cooperate with clinical trials due to other medical conditions (12) Suspected or confirmed history of alcohol or drug abuse (13) Have participated in other clinical trials or are participating in other drug clinical trials within the last 3 months The investigators did not consider it appropriate to participate in clinical trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Influenza symptom remission time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Antipyretic onset time/Complete antipyretic time;Curative effect of TCM syndrome;Single symptom disappearance time and disappearance rate;Complication occurrence rate;Use of antibiotics, antipyretic and analgesic drugs;C-reactive protein;Total clinical symptoms of influenza - area under time curve; | — |
Countries
China
Contacts
Public ContactZhang Hong-chun
China-Japan Friendship Hospital
Outcome results
None listed