Post-Stroke Attention Disorder
Conditions
Interventions
iTBS group:Intermittent theta pulse stimulation (iTBS)
Control group:sham-iTBS
Sponsors
Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) first stroke meeting the diagnostic criteria established by the Fourth National Cerebrovascular Disease Academic Conference in 1995 confirmed by MRI or CT. (2) stabilized vital signs and neurological symptoms, course of stroke between 2 weeks and 6 months. (3) age 30–80 years old, right-handed. (4) mild or moderate cognitive impairment, defined by Montreal Cognitive Assessment (MOCA) score =10 and < 26, with evidence of attention deficit initially screened by MOCA (attention function score = 4 ) and digit span test (digits forwards/backwards < 5). (5) patients can cooperate to complete the scale assessment without mental illness or communication barriers. (6) sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) patients with brain diseases other than cerebrovascular diseases, such as brain trauma, encephalitis, brain tumors, etc. (2) cognitive impairment that occurred before stroke or caused by Alzheimer's disease, Parkinson’s disease, dementia with Lewy bodies, etc. (3) history of substance or alcohol abuse, premorbid seizures, or neuropsychiatric diseases. (4) contraindications involving TMS and MRS (e.g., skull defect or skin damage at the stimulation site, intracranial implants, cardiac pacemakers, implanted drug pumps, etc). (5) serious impairments of the heart, lung, liver, kidney, and other organs, cannot tolerate training. (6) unable to cooperate with assessment and treatment due to severe visual, hearing, or speech impairment; (7) patients who had received TMS treatment or are currently participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall cognition; Attention Span; | — |
Secondary
| Measure | Time frame |
|---|---|
| selective attention, sustained attention, divided attention, shifting attention;Electrophysiological Assessment;Imaging evaluation; | — |
Countries
China
Contacts
Public ContactLu Min
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed