Comparison of ddPCR and mNGS in the clinical application of septic shock patients with abdominal infection

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300068668

Enrollment

Unknown

Registered

2023-02-27

Start date

2023-03-01

Completion date

Unknown

Last updated

2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic shock

Interventions

ddPCR group:ddPCR detection to guide antibiotic targeted therapy.

mNGS group:mNGS to guide antibiotic targeted therapy

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Subjects over 18 years old. 2.New patients in ICU. 3.Patients with septic shock: (1) Infection; (2) SOFA score change >= 2; (3) Hypotension (map 2.5mmol/L could not be corrected by rehydration. 4.Patients with intra-abdominal infection. 5.Subjects who signed informed consent.

Exclusion criteria

Exclusion criteria: 1.Patients whose condition can't be reversed or dying. 2.The subjects who have the intention to stop or cancel the artificial life support (give up treatment). 3.Pregnant or lactating women.

Design outcomes

Primary

Measure	Time frame
The effective rate of targeted antibiotic treatment of 3 days;	—

Secondary

Measure	Time frame
Pathogen detection rate and detection time;Use and economic indicators of antibiotics;Organ function evaluation;28-day mortality;	—

Countries

China

Contacts

Public ContactYang Chunhua, Chen Lei

The Sixth Affiliated Hospital, Sun Yat-sen University

chenlei6@mail.sysu.edu.cn13602728896/13570236595

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026