post-stroke cognitive impairment (PSCI)
Conditions
Interventions
intervention group 1:1. routine medical treatment and rehabilitation training
2. rTMS under multi-modal MRI positioning
intervention group 2:1. routine medical treatment and rehabilitation training
2. rTMS under traditional positioning
control group:1. routine medical treatment and rehabilitation training
2. Sham rTMS
Sponsors
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. First stroke, the lesion was located on the left side, and the duration was less than one month; 2. Aged from 45 to 75years; 3. Right-handed; 4. Cognitive dysfunction (MMSE, MoCA); 5. No drugs affecting cognitive function were taken before enrollment; 6. Being conscious and able to cooperate with the treatment and examination; 7. No other serious physical and intracranial lesions (tumor, infection, etc.); 8. Patients or their family members sign informed consent forms.
Exclusion criteria
Exclusion criteria: 1. The disease is unstable or progressive stroke; 2. Recurrent stroke; 3. Multiple focal stroke; 4. Past history of epilepsy, cognitive impairment or mental illness; 5. Complicated with severe dysfunction of heart, lung, liver, kidney or other serious physical diseases; 6. Cognitive impairment caused by other reasons; 7. Have metal foreign body or other implanted electronic device or skull defect; 8. Patients cannot cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| minimum mental state examination(MMSE);the Montreal cognitive assessment scale (MoCA);Regional Homogeneity(ReHo);amplitude of low-frequency fluctuations(ALFF);Degree Centrality(DC);Network connection within DMN;Topology properties of brain network; | — |
Secondary
| Measure | Time frame |
|---|---|
| Event-related potential P300; | — |
Countries
China
Contacts
Public ContactYamei Li
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Outcome results
None listed