Low dose esketamine combined with closed loop target controlled infusion technique for optimizing opiate-free drugs

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300068653

Enrollment

Unknown

Registered

2023-02-27

Start date

2023-03-01

Completion date

Unknown

Last updated

2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gynecological laparoscopic surgery

Interventions

Opioid-Free Group:Opiates were not used during the perioperative period

Opioid Group:Perioperative use of opioids

Eligibility

Sex/Gender

Female

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: (1) Elective gynecological laparoscopic surgery was performed for the first time; (2) ASA I-II; (3) Age 20-60 years old; (4) Be willing to accept research and sign research application form.

Exclusion criteria

Exclusion criteria: (1) A long history of opioid use (2) pregnant people (3) Patients who vomited or took antiemetics within 24 hours before surgery (4) motion sickness patients (5) Allergic patients to experimental drugs (esketamine, dexmedetomidine, local anesthetics, non-steroidal drugs, opioids, etc.) (6) Bradycardia, sick sinus syndrome, atrioventricular block (7) BMI > 30kg/m2

Design outcomes

Primary

Measure	Time frame
Incidence of ORADEs;	—

Secondary

Measure	Time frame
Postoperative pain score;	—

Countries

China

Contacts

Public ContactTan Fang

The Seventh Affiliated Hospital of Sun Yat-Sen University

734676739@qq.com13725496692

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026