Feeding intolerance and growth failure in premature infants
Conditions
Interventions
Interventions group:taste of milk with every tube feed, administered by the bedside nurse
Control group:Routine care with tube feeding, no milk in the mouth.
Sponsors
Guangdong Women and Children Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. preterm infants born at less than 34 weeks' PMA and/or birth weight less than 2000g with written informed parental/guardian consent 2. Need tube feed 3. vital signs stable 4. Admission within 24 hours after birth
Exclusion criteria
Exclusion criteria: 1 Congenital conditions associated with the digestive system requiring surgery shortly after birth, for example, gastroschisis, any malformation requiring a stoma at birth (eg, anal atresia), oesophageal atresia; 2 congenital conditions leading to impaired growth, for example, trisomy 21
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight z-score at discharge from hospital based on the Fenton growth charts; | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight at 36 weeks' PMA;Head circumference at 36 weeks’ PMA and at discharge home;Length at 36 weeks’ PMA and at discharge home;Time to regain birth weight(day);Time (days) to full enteral feeds (120mL/kg/d for at least 24hours);Duration of parenteral nutrition (days) total;Time to reach full sucking feeds:defined as the time required to start oral feeding to reach full oral feeding;PMA at strat oral feed:defined as the first oral bottle feeding = 5ml / time;PMA at full oral feed:defined as oral feeding milk 120ml / kg · d-1, without tube feeding for 48 hours;PMA at removal of nasogastric tube;PMA at discharge home from hospital;Feeding efficiency : defined as per minute oral milk volume;Feeding effectiveness : defined as the proportion of milk intake in the first 5 minutes of oral bottle feeding to the amount of milk prescribed by the doctor.;Milk intake ratio : defined as the ratio of a single oral intake of milk to the amount of milk prescribed by the doctor;Length of hospital stay;Gastric tube remain time;Respiratory support in hours (continuous positive airway pressure or high flow nasal cannula, and endotracheal respiratory support);Type of feeding at different time points (eg, type of milk given);Rate of intervention-related adverse events;Rate and severity of intraventricular haemorrhage;Rate of treated patent ductus arteriosus;Rate and severity of retinopathy of prematurity;Rate of late-onset sepsis, diagnosed after 24hours of life in a symptomatic infant with positive blood culture, cerebrospinal fluid or sterile collected urine, treated for a minimum of 5 days with antibiotics.;Rate of bronchopulmonary dysplasia;Rate and severity of necrotising enterocolitis; | — |
Countries
Chian
Contacts
Public ContactLou Man
Guangdong Women and Children Hospital
Outcome results
None listed